Article
No evidence for association between the interferon regulatory factor 1 (IRF1) gene and clinical tuberculosis.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2009
Vollstedt Sabine, Yuliwulandari Rika, Okamoto Koji, Lien Luu Thi, Keicho Naoto, Rochani Jecti Teguh, Wikaningrum Riyani, Tokunaga Katsushi
Abstract excerpt
Interferon regulatory factor 1 is a transcription factor involved in initiating a vigorous Th1 response during Mycobacterium tuberculosis infection. Therefore, we considered it as a possible candidate gene for certain polymorphisms to confer susceptibility to develop clinical tuberculosis. However, all polymorphisms with minor allele frequencies higher than 5% and haplotype frequencies in two Southeast Asian...
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