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Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease

20 Aug 2007

Abstract excerpt

Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the commonest form of dementia. A buccal cytome assay was used to measure ratios of buccal cell populations and micronuclei in clinically diagnosed Alzheimer's patients compared to age and gender-matched controls. Frequencies of basal cells (P < 0.0001), condensed chromatin cells (P < 0.0001) and karyorrhectic cells (P < 0.0001)...

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PMID: 17709794
DOI: 10.1093/mutage/gem029

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