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Article

Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases.

Scientific reports - 17 Dec 2020

Reimann Hauke, Stopper Helga, Polak Thomas, Lauer Martin, Herrmann Martin J, Deckert Jürgen, Hintzsche Henning

Abstract excerpt

Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other...

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Identifiers

PMID: 33335130
DOI: 10.1038/s41598-020-78832-y
PMCID: PMC7747561

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