Total number of genome alterations in sporadic gastrointestinal cancer inferred from pooled analyses in the literature.

Abstract excerpt

BACKGROUND/AIMS: A previous study based on the age distribution of human cancers has demonstrated that about 6 or 7 mutations are required for gastrointestinal cancer to develop. This study aims to provide further insight into this issue through a systematic review of current knowledge found in the literature. METHODS: The PubMed database was searched for entries up to December 2007 for eligible studies...

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