Article

Identification of genetic sequence variations associated with the pathogenesis of X-linked hyper-IgM syndrome

2021-04-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>X-Linked Hyper-IgM Syndrome (X-HIGM)<bold> </bold>is a rare genetic primary immunodeficiency disease caused by mutations of the CD40 ligand gene (CD40LG). It is characterized by normal or elevated levels of IgM and markedly decreased serum IgG, IgA, and IgE levels. Patients with this syndrome are often prone to infections. Environmental and genetic (especially g...

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Literature Corpus work: 6871a1a3-adf1-5cb4-a122-7cfe3ca42647
DOI: 10.21203/rs.3.rs-370993/v1

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