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Article

Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.

Journal of hepatology - 1 Jan 2009

Mihm Ulrike, Ackermann Oliver, Welsch Christoph, Herrmann Eva, Hofmann Wolf Peter, Grigorian Natalia, Welker Martin Walter, Lengauer Thomas, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND/AIMS: Interferon-alpha induces 2'-5'-oligoadenylate synthetase which activates RNase L. Viral RNA is cleaved by RNase L at UU/UA dinucleotides. The clinical relevance of RNase L cleavage for response to an interferon-alpha-based therapy in chronic hepatitis C is unknown. METHODS: RNase L cleavage sites within pre-treatment sequences coding for structural and non-structural hepatitis C virus proteins...

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Source

Identifiers

PMID: 19022516
DOI: 10.1016/j.jhep.2008.08.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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