Article
Isolation of drug-resistant mutant HIV variants using tissue culture drug selection.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2009
Oliveira Maureen, Brenner Bluma G, Wainberg Mark A
Abstract excerpt
The life cycle of HIV-1 can be affected in different manners by the various classes of antiviral agents. Genetic heterogeneity is a characteristic of this virus, which contributes significantly to the ability of the virus to generate mutations which overcome the efficacy of the drug therapy. The selection of drug resistant mutants in vitro can be readily accomplished by maintaining the virus in a state of...
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