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Article

HIV-1 drug-resistance and drug-dependence.

Retrovirology - 25 Oct 2007

Baldwin Chris, Berkhout Ben

Abstract excerpt

In this review, we will describe several recent HIV-1 studies in which a drug-dependent virus variant was selected. A common evolutionary route to the drug-dependence phenotype is proposed. First, the selection of a drug-resistance mutation that also affects the function of the targeted viral protein. Second, a compensatory mutation that repairs the protein function, but in the presence of the drug, which becomes...

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Identifiers

PMID: 17961213
DOI: 10.1186/1742-4690-4-78
PMCID: PMC2129100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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