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Article

Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management.

Endocrinology, diabetes & metabolism - 1 Mar 2026

Ngcobo Nokwanda N, Sibiya Ntethelelo H

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a complex, multifactorial disease influenced by interactions between environmental exposures and genetic determinants. Increasing evidence highlights the important role of genetic variation in disease susceptibility, progression, and therapeutic response. AIM: This review aims to explore key genetic factors associated with T2DM risk and pathogenesis, as well as...

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Share to Cytochrome P-450 Enzyme System
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDKN2A gene

Share to KCNJ11 gene

Share to Genetic Predisposition to Disease

Share to Hypoglycemic Agents

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Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 41872653
DOI: 10.1002/edm2.70204
PMCID: PMC13093510

Genes

CDKN2A
HNF4A
IGF2BP2
KCNJ11
KLF14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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