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Article

The ABC protein turned chloride channel whose failure causes cystic fibrosis.

Nature - 23 Mar 2006

Gadsby David C, Vergani Paola, Csanády László

Abstract excerpt

CFTR chloride channels are encoded by the gene mutated in patients with cystic fibrosis. These channels belong to the superfamily of ABC transporter ATPases. ATP-driven conformational changes, which in other ABC proteins fuel uphill substrate transport across cellular membranes, in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient. New structural and biochemical...

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Share to Adenosine Triphosphate
Share to ATP-Binding Cassette Transporters
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Hydrolysis

Share to Ion Channel Gating

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Source

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Identifiers

PMID: 16554808
DOI: 10.1038/nature04712
PMCID: PMC2720541

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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