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Infectious Molecular Clones of Adeno-Associated Virus Isolated Directly from Human Tissues

20 Nov 2008

Abstract excerpt

Adeno-associated virus (AAV) replication and biology have been extensively studied using cell culture systems, but there is precious little known about AAV biology in natural hosts. As part of our ongoing interest in the in vivo biology of AAV, we previously described the existence of extrachromosomal proviral AAV genomes in human tissues. In the current work, we describe the molecular structure of infectious DNA...

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PMID: 19019948
DOI: 10.1128/jvi.01686-08

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