Article
Cystic fibrosis gene variability in two southern Brazilian Amerindian populations: analysis of the deltaF508 mutation and the KM19 and XV2C haplotypes.
Human biology - 1 Feb 2007
Raskin S, Petzl-Erler M L, Phillips J A, Pereira-Ferrari L, Probst C M, Faucz F R, Sotomaior V, Salzano F M, Culpi L
Abstract excerpt
The frequencies of the deltaF508 deletion, the most common cystic fibrosis mutation in Europeans and European-derived populations, and the XV2C and KM19 restriction fragment length polymorphisms that are tightly linked to the CFTR locus vary among populations. To determine the distribution of these extragenic markers and of the deltaF508 mutation, we analyzed 326 chromosomes of individuals from two South American...
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