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Cancer stem cells and chemoradiation resistance

1 Oct 2008

Abstract excerpt

Cancer is a disease of genetic and epigenetic alterations, which are emphasized as the central mechanisms of tumor progression in the multistepwise model. Discovery of rare subpopulations of cancer stem cells (CSCs) has created a new focus in cancer research. The heterogeneity of tumors can be explained with the help of CSCs supported by antiapoptotic signaling. CSCs mimic normal adult stem cells by demonstrating...

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PMID: 19016744
DOI: 10.1111/j.1349-7006.2008.00914.x

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