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Article

ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

2 Mar 2005

Abstract excerpt

Down's syndrome (DS) is characterized by mental retardation and development of Alzheimer's disease (AD). Oxidative stress and mitochondrial dysfunction are both related to neurodegeneration in DS. Several genes in chromosome 21 have been linked to neuronal death, including the transcription factor ets-2. Cortical cultures derived from normal and DS fetal brains were used to study the role of ets-2 in DS neuronal...

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PMID: 15745955
DOI: 10.1523/jneurosci.5107-04.2005

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