Article
Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis.
Gastroenterology - 1 Dec 2008
Boparai Karam S, Dekker Evelien, Van Eeden Susanne, Polak Mirjam M, Bartelsman Joep F W M, Mathus-Vliegen Elisbeth M H, Keller Josbert J, van Noesel Carel J M
Abstract excerpt
BACKGROUND & AIMS: MYH-associated polyposis (MAP) is a disorder caused by a bi-allelic germline MYH mutation, characterized by multiple colorectal adenomas. These adenomas typically harbor G:C-->T:A transversions in the APC and K-ras genes caused by MYH deficiency. Occasional hyperplastic polyps (HPs) have been described in MAP patients but a causal relationship has never been investigated. We examined the...
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