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Article

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.

British journal of cancer - 4 Jun 2007

Thirlwell C, Howarth K M, Segditsas S, Guerra G, Thomas H J W, Phillips R K S, Talbot I C, Gorman M, Novelli M R, Sieber O M, Tomlinson I P M

Abstract excerpt

Patients with multiple (5-100) colorectal adenomas (MCRAs) often have no germline mutation in known predisposition genes, but probably have a genetic origin. We collected a set of 25 MCRA patients with no detectable germline mutation in APC, MYH/MUTYH or the mismatch repair genes. Extracolonic tumours were absent in these cases. No vertical transmission of the MCRA phenotype was found. Based on the precedent of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17505512
DOI: 10.1038/sj.bjc.6603789
PMCID: PMC2359923

Genes

APC
MUTYH
BRAF
FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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