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Article

Increased constraints on MC4R during primate and human evolution.

Human genetics - 1 Jan 2009

Hughes David A, Hinney Anke, Brumm Harald, Wermter Anne-Kathrin, Biebermann Heike, Hebebrand Johannes, Stoneking Mark

Abstract excerpt

The melanocortin 4 receptor (MC4R) is routinely investigated for the role it plays in human obesity, as mutations in MC4R are the most common dominantly inherited form of the disease. As little is known about the evolutionary history of this locus, we investigated patterns of variation at MC4R in...

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Identifiers

PMID: 19011902
DOI: 10.1007/s00439-008-0591-8
PMCID: PMC9947067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19011902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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