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Article

High polymorphism at the human melanocortin 1 receptor locus.

Genetics - 1 Apr 1999

Rana B K, Hewett-Emmett D, Jin L, Chang B H, Sambuughin N, Lin M, Watkins S, Bamshad M, Jorde L B, Ramsay M, Jenkins T, Li W H

Abstract excerpt

Variation in human skin/hair pigmentation is due to varied amounts of eumelanin (brown/black melanins) and phaeomelanin (red/yellow melanins) produced by the melanocytes. The melanocortin 1 receptor (MC1R) is a regulator of eu- and phaeomelanin production in the melanocytes, and MC1R mutations causing coat color changes are known in many mammals. We have sequenced the MC1R gene in 121 individuals sampled from...

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Identifiers

PMID: 10101176
DOI: 10.1093/genetics/151.4.1547
PMCID: PMC1460552

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Source receipt: pubmed, retrieved 7 Sept 2026.

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