Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of nuclear p27 expression and its prognostic role in relation to cyclin E and p53 mutation in gastroenteropancreatic neuroendocrine tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2008

Grabowski Patricia, Schrader Jörg, Wagner Julia, Hörsch Dieter, Arnold Rudolf, Arnold Christian N, Georgieva Inna, Stein Harald, Zeitz Martin, Daniel Peter T, Sturm Isrid

Abstract excerpt

PURPOSE: Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are classified by the WHO, yet its prognostic value needs to be confirmed. Therefore, we aimed to determine the prognostic role of cell cycle key regulatory genes p53, p27kip1 (p27), and cyclin E in this tumor entity. EXPERIMENTAL DE...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin E

Share to Digestive System Neoplasms

Share to Kaplan-Meier Estimate

Share to Neuroendocrine Tumors

Share to Oncogene Proteins

Share to Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 19010853
DOI: 10.1158/1078-0432.CCR-08-0698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19010853-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of nuclear p27 expression and its prognostic role in relation to cyclin E and p53 mutation in gastroenteropancreatic neuroendocrine tumors.PMID 19010853Read ↗

Altered miRNAs Expression Correlates With Gastroenteropancreatic Neuroendocrine Tumors GradesSemantic proximity Read ↗

Biological and molecular aspects of gastroenteropancreatic neuroendocrine tumors.Semantic proximity Read ↗

Different molecular profiles characterize well-differentiated endocrine tumors and poorly differentiated endocrine carcinomas of the gastroenteropancreatic tract.Semantic proximity Read ↗

Morphological, molecular, and prognostic aspects of gastric endocrine tumorsSemantic proximity Read ↗

Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORFSemantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma.Semantic proximity Read ↗

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis.Semantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

High level expression of p27 <sup>kip1</sup> and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 <sup>kip1</sup> and degree of malignancy in human breast and colorectal cancersSemantic proximity Read ↗

p53 tumour suppressor gene expression in pancreatic neuroendocrine tumour cells.Semantic proximity Read ↗

Cyclin E, p27 and mutant p53 do not predict the prognosis in AJCC stage II colorectal carcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.