Article
Experimentally increased codon bias in the Drosophila Adh gene leads to an increase in larval, but not adult, alcohol dehydrogenase activity.
Genetics - 1 Feb 2010
Hense Winfried, Anderson Nathan, Hutter Stephan, Stephan Wolfgang, Parsch John, Carlini David B
Abstract excerpt
Although most amino acids can be encoded by more than one codon, the synonymous codons are not used with equal frequency. This phenomenon is known as codon bias and appears to be a universal feature of genomes. The translational selection hypothesis posits that the use of optimal codons, which match the most abundant species of isoaccepting tRNAs, results in increased translational efficiency and accuracy....
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