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Article

The role of abnormal trafficking of KCNE1 in long QT syndrome 5.

Biochemical Society transactions - 1 Nov 2007

Harmer S C, Tinker A

Abstract excerpt

LQTS (long QT syndrome) is an important cause of cardiac sudden death. LQTS is characterized by a prolongation of the QT interval on an electrocardiogram. This prolongation predisposes the individual to torsade-de-pointes and subsequent sudden death by ventricular fibrillation. Mutations in a number of genes that encode ion channels have been implicated in LQTS. Hereditary mutations in the alpha- and...

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Topics

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Share to KCNQ1 gene
Share to KCNQ1 Potassium Channel
Share to Long QT Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Potassium Channels, Voltage-Gated

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Source

Identifiers

PMID: 17956282
DOI: 10.1042/BST0351074

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of abnormal trafficking of KCNE1 in long QT syndrome 5.PMID 17956282Read ↗

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Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome.Semantic proximity Read ↗

Biology of cardiac arrhythmias: ion channel protein trafficking.Semantic proximity Read ↗

Mapping the Functional Landscape of KCNQ1 to Define Ion Channel Mechanisms and Arrhythmia RiskSemantic proximity Read ↗

Long QT syndrome: ionic basis and arrhythmia mechanism in long QT syndrome type 1.Semantic proximity Read ↗

Characterization of an LQT5-related mutation in KCNE1, Y81C: implications for a role of KCNE1 cytoplasmic domain in IKs channel function.Semantic proximity Read ↗

Integrative analysis of KCNQ1 variants reveals molecular mechanisms of type 1 long QT syndrome pathogenesisSemantic proximity Read ↗

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