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Article

Promoter methylation confers kidney‐specific expression of the <i>Klotho</i> gene

10 Jul 2012

Abstract excerpt

The aging suppressor geneKlotho is predominantly expressed in the kidney irrespective of species. Because Klotho protein is an essential component of an endocrine axis that regulates renal phosphate handling, the kidney-specific expression is biologically relevant; however, little is known about its underlying mechanisms. Here we provide in vitro and in vivo evidence indicating that promoter methylation restricts...

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PMID: 22782974
DOI: 10.1096/fj.12-211631

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Promoter methylation confers kidney‐specific expression of the <i>Klotho</i> genePMID 22782974Read ↗

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