Article
Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Aug 2013
Abreu Cecilia, Moreno Pilar, Palacios Florencia, Borge Mercedes, Morande Pablo, Landoni Ana Inés, Gabus Raul, Dighiero Guillermo, Giordano Mirta, Gamberale Romina, Oppezzo Pablo
Abstract excerpt
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue...
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