Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The expression of NMDA receptor subunit mRNA in human chronic alcoholics.

Annals of the New York Academy of Sciences - 1 Oct 2008

Ridge Justin P, Ho Ada M-C, Innes David J, Dodd Peter R

Abstract excerpt

Ethanol is a modulator at the N-methyl-d-aspartate class of glutamate receptors in the brain. In animal studies the receptor adapts to sustained ethanol exposure through altered expression of the subunits that make up the receptor complex. We used real-time RT-PCR normalized to GAPDH to assay NR1, NR2A, and NR2B subunit mRNA in superior frontal and primary motor cortex tissue obtained at autopsy from chronic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Cerebral Cortex
Share to Ethanol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis

Share to Protein Subunits

Share to Receptors, N-Methyl-D-Aspartate

Share to Regression Analysis

Share to Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18991843
DOI: 10.1196/annals.1432.053
PMCID: PMC3821866

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The expression of NMDA receptor subunit mRNA in human chronic alcoholics.PMID 18991843Read ↗

Cortical NMDA receptor expression in human chronic alcoholism: influence of the TaqIA allele of ANKK1.Semantic proximity Read ↗

Genes and gene expression in the brain of the alcoholic.Semantic proximity Read ↗

Altered Gene Expression Profiles in the Frontal Cortex of Cirrhotic AlcoholicsSemantic proximity Read ↗

GlutamateNMDA receptor NR1 subunit mRNA expression in Alzheimer's diseaseSemantic proximity Read ↗

Sex differences in GABAA receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver.Semantic proximity Read ↗

[The NMDA receptor system: genetic risk factor for alcoholism].Semantic proximity Read ↗

NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy.Semantic proximity Read ↗

N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal.Semantic proximity Read ↗

GABA(A) receptor beta isoform protein expression in human alcoholic brain: interaction with genotype.Semantic proximity Read ↗

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.Semantic proximity Read ↗

Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action.Semantic proximity Read ↗

Ethanol and gene expression in brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.