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Article

Parent-of-origin effects propagate through networks to shape metabolic traits.

eLife - 31 Mar 2022

Macias-Velasco Juan F, St Pierre Celine L, Wayhart Jessica P, Yin Li, Spears Larry, Miranda Mario A, Carson Caryn, Funai Katsuhiko, Cheverud James M, Semenkovich Clay F, Lawson Heather A

Abstract excerpt

Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and neurological traits. Parent-of-origin effects can be modified by the environment, but the architecture of these gene-by-environmental effects on phenotypes remains to be unraveled. Previously, quantitative trait loci (QTL) showing context-specific parent-of-origin effects on metabolic traits were mapped in the F16...

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PMID: 35356864
DOI: 10.7554/eLife.72989
PMCID: PMC9075957

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