Article
Association between non-Hodgkin lymphoma and haplotypes in the TNF region.
British journal of haematology - 1 May 2006
Spink Charlotte F, Keen Leigh J, Mensah Fiona K, Law Graham R, Bidwell Jeff L, Morgan Gareth J
Abstract excerpt
The cytokines tumour necrosis factor-alpha (TNFalpha) and lymphotoxin-alpha (LTalpha) are known to play key roles in B-cell growth, differentiation and maturation. Genetic polymorphism within regulatory regions of these cytokine genes can alter expression levels and may be important in development of lymphoid malignancy. This study investigates a number of single nucleotide polymorphisms (SNPs) and microsatellite...
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