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Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factors.

Cancer research - 15 May 2007

Wang Sophia S, Cozen Wendy, Cerhan James R, Colt Joanne S, Morton Lindsay M, Engels Eric A, Davis Scott, Severson Richard K, Rothman Nathaniel, Chanock Stephen J, Hartge Patricia

Abstract excerpt

Two common single nucleotide polymorphisms in immunoregulatory genes (TNF G308A, rs1800629 and IL10 T3575A, rs1800890) have been recently reported as risk factors for non-Hodgkin lymphoma (NHL) in a large pooled analysis. We systematically investigated the effects of other established NHL risk factors in relation to the tumor necrosis factor (TNF) G308A or interleukin 10 (IL10) T3575A genotypes. We calculated...

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PMID: 17510437
DOI: 10.1158/0008-5472.CAN-06-4752

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TNF

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