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Article

Preferences of transmembrane helices for cooperative amplification of G(alpha)s and G (alpha)q signaling of the thyrotropin receptor.

Cellular and molecular life sciences : CMLS - 1 Dec 2008

Jaeschke H, Kleinau G, Sontheimer J, Mueller S, Krause G, Paschke R

Abstract excerpt

The majority of constitutively activating mutations (CAMs) of the thyroid-stimulating hormone receptor display a partially activated receptor. Thus, full receptor activation requires a multiplex activation process. To define impacts of different transmembrane helices (TMHs) on cooperative signal transduction, we combined single CAMs in particular TMHs to double mutations and measured second messenger accumulation...

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Identifiers

PMID: 18989620
DOI: 10.1007/s00018-008-8530-3
PMCID: PMC11131724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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