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Article

Modulation of monocyte chemotactic function in inflammatory lesions. Role of inflammatory mediators.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991

Katona I M, Ohura K, Allen J B, Wahl L M, Chenoweth D E, Wahl S M

Abstract excerpt

Monocyte recruitment and accumulation in the synovial tissue is pivotal in the evolution of rheumatoid arthritis (RA). In the present study we examined the chemotactic potential of monocytes obtained from synovial fluid (SF) of patients with RA. Functionally, SF monocytes exhibited greatly diminished chemotactic activity to C5a compared with monocytes from the peripheral blood. In contrast, their chemotactic...

Topics

Adult
Arthritis, Rheumatoid
Chemotaxis, Leukocyte
Complement C5a
Cytokines
Humans
Interferon-gamma
Monocytes
N-Formylmethionine Leucyl-Phenylalanine
Phenotype
Receptor, Anaphylatoxin C5a

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Complement

Receptors, Formyl Peptide

Receptors, Immunologic

Synovial Fluid

Source

Identifiers

PMID: 1898961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1898961-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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