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Article

Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans.

Journal of bacteriology - 1 Jan 1991

Jacobson E S, Emery H S

Abstract excerpt

Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidation to melanin. Catecholamine metabolism appears to protect C. neoformans from oxidants.

Topics

Biological Transport
Catecholamines
Crosses, Genetic
Cryptococcus neoformans
Genes, Bacterial
Genetic Linkage
Melanins
Monophenol Monooxygenase
Mutation
Oxygen
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1898925
DOI: 10.1128/jb.173.1.401-403.1991
PMCID: PMC207201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1898925-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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