Melanization affects susceptibility of Cryptococcus neoformans to heat and cold1

doi:10.1111/j.1574-6968.1997.tb12584.x

Article

Melanization affects susceptibility of Cryptococcus neoformans to heat and cold1

17 Jan 2006

Abstract excerpt

Cryptococcus neoformans can synthesize melanin from a variety of substrates, including L-dopa (L-3,4-dihydroxyphenylalanine). Growth in minimal medium with L-dopa resulted in progressive accumulation of melanin in stationary phase cells. Melanized and non-melanized yeast cells were exposed to heat (42-47 degrees C) and cold (-20 degrees C), and the percentage of survival determined. Melanized cells were less...

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