Oxygen induces mutation in a strict anaerobe, Prevotella melaninogenica.

doi:10.1016/j.freeradbiomed.2008.02.003

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Article

Oxygen induces mutation in a strict anaerobe, Prevotella melaninogenica.

Free radical biology & medicine - 15 May 2008

Takumi Shota, Komatsu Masaharu, Aoyama Kohji, Watanabe Kunitomo, Takeuchi Toru

Abstract excerpt

Strict anaerobes are highly sensitive to oxygen, but the mutagenicity of oxygen in strict anaerobes has not been well understood. Prevotella melaninogenica, a strict anaerobe, is susceptible to oxygen and shows an increase in oxidative DNA damage upon exposure to oxygen. In this study, we have investigated the mutagenicity of oxygen and the types of mutations induced by oxygen. Exposure to oxygen decreased cell...

Topics

8-Hydroxy-2'-Deoxyguanosine
Amino Acid Sequence
Antibiotics, Antitubercular
Bacterial Proteins
DNA Damage
Deoxyguanosine
Molecular Sequence Data
Mutation
Oxygen
Prevotella melaninogenica
Rifampin

Source

Open in PubMed

Identifiers

PMID: 18343236
DOI: 10.1016/j.freeradbiomed.2008.02.003

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