Article
Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression.
Journal of Zhejiang University. Science. B - 1 Nov 2008
Zhu Zhong-Zheng, Liu Bing, Wang Ai-Zhong, Jia Hang-Ruo, Jin Xia-Xiang, He Xiang-Lei, Hou Li-Fang, Zhu Guan-Shan
Abstract excerpt
OBJECTIVE: To evaluate the association between p53 codon 72 polymorphism (R72P) and the risk of colorectal liver metastases. METHODS: The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. RESULTS: The R...
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