Article
[Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2005
Zhu Zhong-zheng, Cong Wen-ming, Zhu Guan-shan, Liu Shu-fang, Xian Zhi-hong, Wu Wei-qing, Zhang Xiu-zhong, Wang Yan-hua, Wu Meng-chao
Abstract excerpt
OBJECTIVE: A functional single nucleotide polymorphism (SNP) at codon 72 of the gene for p53 protein (p53 R72P) has been implicated in a variety of human cancers, but the relationship between this SNP and hepatocellular carcinoma (HCC) remains obscure despite the fact that the critical role of p5...
Topics
- Asian People
- Carcinoma, Hepatocellular
- China
- Codon
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Linkage Disequilibrium
- Liver Neoplasms
- Male
- Polymerase Chain Reaction
- Polymorphism, Single Nucleotide