Article
[Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2005
Zhu Zhong-zheng, Cong Wen-ming, Zhu Guan-shan, Liu Shu-fang, Xian Zhi-hong, Wu Wei-qing, Zhang Xiu-zhong, Wang Yan-hua, Wu Meng-chao
Abstract excerpt
OBJECTIVE: A functional single nucleotide polymorphism (SNP) at codon 72 of the gene for p53 protein (p53 R72P) has been implicated in a variety of human cancers, but the relationship between this SNP and hepatocellular carcinoma (HCC) remains obscure despite the fact that the critical role of p53 protein in HCC has been documented. This study was conducted to evaluate the link between the polymorphism with HCC...
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