Article
CLIC1 function is required for beta-amyloid-induced generation of reactive oxygen species by microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2008
Milton Rosemary H, Abeti Rosella, Averaimo Stefania, DeBiasi Silvia, Vitellaro Laura, Jiang Lele, Curmi Paul M G, Breit Samuel N, Duchen Michael R, Mazzanti Michele
Abstract excerpt
The Alzheimer's disease (AD) brain is characterized by plaques containing beta-amyloid (Abeta) protein surrounded by astrocytes and reactive microglia. Activation of microglia by Abeta initiates production of reactive oxygen species (ROS) by the plasmalemmal NADPH oxidase; the resultant oxidative stress is thought to contribute to neurodegeneration in AD. We have previously shown that Abeta upregulates a chloride...
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