Article
Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126.
Development (Cambridge, England) - 1 Dec 2008
Kuhnert Frank, Mancuso Michael R, Hampton Jessica, Stankunas Kryn, Asano Tomoichiro, Chen Chang-Zheng, Kuo Calvin J
Abstract excerpt
Intronic microRNAs have been proposed to complicate the design and interpretation of mouse knockout studies. The endothelial-expressed Egfl7/miR-126 locus contains miR-126 within Egfl7 intron 7, and angiogenesis deficits have been previously ascribed to Egfl7 gene-trap and lacZ knock-in mice. Surprisingly, selectively floxed Egfl7(Delta) and miR-126(Delta) alleles revealed that Egfl7(Delta/Delta) mice were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.