Article
Th1-type immune response to infection by pYV-cured phoP-phoQ null mutant of Yersinia pseudotuberculosis is defective in mouse model.
Antonie van Leeuwenhoek - 1 Jan 2009
Kumar Subodh, Balakrishna K, Agarwal G S, Merwyn S, Rai G P, Batra H V, Sardesai A A, Gowrishankar J
Abstract excerpt
The PhoP-PhoQ two-component system of Yersinia pseudotuberculosis, a Gram-negative enteric pathogen which causes a variety of gastrointestinal and extraintestinal infections in humans, has been shown to be necessary for virulence. A phoP-phoQ null mutant of a strain of Y. pseudotuberculosis cured of its native plasmid pYV was obtained and studied for generation of immune response in mouse model following...
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