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Article

Kremen1 regulates mechanosensory hair cell development in the mammalian cochlea and the zebrafish lateral line.

Scientific reports - 23 Aug 2016

Mulvaney Joanna F, Thompkins Cathrine, Noda Teppei, Nishimura Koji, Sun Willy W, Lin Shuh-Yow, Coffin Allison, Dabdoub Alain

Abstract excerpt

Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the adult mouse cochlea. Based on this expression pattern, we investigated whether Kremen1 functions...

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Identifiers

PMID: 27550540
DOI: 10.1038/srep31668
PMCID: PMC4994024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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