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Article

ICAM-2 expression mediates a membrane-actin link, confers a nonmetastatic phenotype and reflects favorable tumor stage or histology in neuroblastoma.

PloS one - 1 Jan 2008

Yoon Karina Jin, Phelps Doris A, Bush Rebecca A, Remack Joanna S, Billups Catherine A, Khoury Joseph D

Abstract excerpt

The actin cytoskeleton is a primary determinant of tumor cell motility and metastatic potential. Motility and metastasis are thought to be regulated, in large part, by the interaction of membrane proteins with cytoplasmic linker proteins and of these linker proteins, in turn, with actin. However, complete membrane-to-actin linkages have been difficult to identify. We used co-immunoprecipitation and competitive...

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Identifiers

PMID: 18978946
DOI: 10.1371/journal.pone.0003629
PMCID: PMC2575377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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