Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus.

doi:10.1016/j.febslet.2008.10.032

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Article

Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus.

FEBS letters - 26 Nov 2008

Malcolm Tom, Kam Joanna, Pour Pouya Sadeghi, Sadowski Ivan

Abstract excerpt

RBF-2 is a factor comprised of a USF1/2 heterodimer, whose association with a highly conserved upstream element (RBEIII) on the HIV-1 LTR requires a co-factor TFII-I. We have identified specific nucleotides, immediately 3' of RBEIII that are required for stable association of TFII-I with this region of the LTR. Mutations that inhibit interaction of TFII-I with DNA also prevent stimulation of USF binding to...

Topics

Base Sequence
Gene Expression Regulation, Viral
HIV Long Terminal Repeat
HIV-1
Humans
Jurkat Cells
Mutation
Proviruses
Transcription Factors, TFII
Upstream Stimulatory Factors
Virus Activation

Source

Open in PubMed

Identifiers

PMID: 18976654
DOI: 10.1016/j.febslet.2008.10.032

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