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Article

Tethering human immunodeficiency virus type 1 preintegration complexes to target DNA promotes integration at nearby sites

1 Jan 1997

Abstract excerpt

Integration of retroviral cDNA in vivo is normally not sequence specific with respect to the integration target DNA. We have been investigating methods for directing the integration of retroviral DNA to predetermined sites, with the dual goal of understanding potential mechanisms governing normal site selection and developing possible methods for gene therapy. To this end, we have fused retroviral integrase...

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Identifiers

PMID: 8985371
DOI: 10.1128/jvi.71.1.458-464.1997

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