Article
Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.
Biochemical Society transactions - 1 Jun 2008
Gloyn Anna L, Tribble Nicholas D, van de Bunt Martijn, Barrett Amy, Johnson Paul R V
Abstract excerpt
There are well-documented examples in the literature of where determining the genetic aetiology of a disorder has provided insights into important regulatory pathways and protein interactions, and, more recently, has led to improved treatment options for patients. The studies of monogenic forms of beta-cell dysfunction are no exception. Naturally occurring mutations in the gene for the beta-cell enzyme...
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