Article
Characterization of the attenuating M and NP gene segments of the avian influenza A/Mallard/78 virus during in vitro production of avian-human reassortant vaccine viruses and after replication in humans and primates.
Vaccine - 1 Jul 1991
Treanor J J, Tierney E L, London W T, Murphy B R
Abstract excerpt
A unique requirement for live attenuated reassortant influenza vaccines is the need to generate new reassortant vaccine viruses with the appearance of each new antigenic variant. Thus, the attenuation phenotype conferred by the attenuated donor influenza virus must remain genetically stable during the generation of each new reassortant vaccine virus. In this study we used nucleotide sequence analysis to evaluate...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Humans
- Influenza A virus
- Influenza Vaccines
- Molecular Sequence Data
- Mutation
- Nucleocapsid Proteins
- Nucleoproteins