Effect of reassortment on the nucleotide and amino acid changes of human A/H3N2 RNP subunits during 1998-2009.

doi:10.1016/j.jcv.2011.05.013

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Article

Effect of reassortment on the nucleotide and amino acid changes of human A/H3N2 RNP subunits during 1998-2009.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Aug 2011

Wong Karen Ka Yin, Bull Rowena A, Stelzer-Braid Sacha, Fennell Michael, Rawlinson William

Abstract excerpt

BACKGROUND: The ribonucleoprotein (RNP) complex of influenza virus consists of four subunits PB2, PB1, PA, and NP, which are essential for replication. While reassortment plays an important role in the evolution and virulence of influenza viruses, limited studies have investigated the effect of reassortment on the evolution of the internal RNP subunits. OBJECTIVE: To examine the effect of reassortment on the...

Topics

Amino Acid Substitution
Australia
Cluster Analysis
Evolution, Molecular
Genotype
Humans
Influenza A Virus, H3N2 Subtype
Influenza, Human
Molecular Sequence Data
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Protein Subunits

RNA, Viral

Reassortant Viruses

Sequence Analysis, DNA

Sequence Homology

Viral Proteins

Source

Open in PubMed

Identifiers

PMID: 21665531
DOI: 10.1016/j.jcv.2011.05.013

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