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The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum.

Microbiology (Reading, England) - 1 Nov 2008

García-Rico Ramón O, Fierro Francisco, Mauriz Elba, Gómez Ana, Fernández-Bodega María Ángeles, Martín Juan F

Abstract excerpt

We have studied the role of the pga1 gene of Penicillium chrysogenum, encoding the alpha subunit of a heterotrimeric G protein, in secondary metabolite production. The dominant activating pga1(G42R) mutation caused an increase in the production of the three secondary metabolites penicillin, the yellow pigment chrysogenin and the mycotoxin roquefortine, whereas the dominant inactivating pga1(G203R) allele and the...

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PMID: 18957609
DOI: 10.1099/mic.0.2008/019091-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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