Article
Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.
Neoplasia (New York, N.Y.) - 1 Jul 2007
Derouet Mathieu, Wu Xue, May Linda, Hoon Yoo Byong, Sasazuki Takehiko, Shirasawa Senji, Rak Janusz, Rosen Kirill V
Abstract excerpt
Detachment from the extracellular matrix causes apoptosis of normal epithelial cells--a phenomenon called anoikis. K-ras oncogene, an established anoikis inhibitor, often occurs in colorectal carcinoma (CRC). In addition to blocking anoikis-inducing mechanisms, oncogenic K-ras can cause anoikis-unrelated changes in CRC cells, such as induction of events promoting their deregulated mitogenesis, ability to trigger...
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