Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Yin and Yang of treating BRCA-deficient tumors.

Cell - 21 Mar 2008

Martin Richard W, Connell Philip P, Bishop Douglas K

Abstract excerpt

The myriad changes that occur during the malignant progression of cancer cells present challenges to both clinicians and basic scientists. Two new studies in Nature underscore the central role of genome instability in tumor biology (Edwards et al., 2008; Sakai et al., 2008). These reports describe secondary changes in the BRCA2 locus that restore the wild-type reading frame and contribute to the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to DNA Repair
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to BRCA2 gene

Share to Genes, BRCA2

Share to Genomic Instability

Share to Models, Biological

Share to Mutation

Source

Identifiers

PMID: 18358803
DOI: 10.1016/j.cell.2008.03.006

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Yin and Yang of treating BRCA-deficient tumors.PMID 18358803Read ↗

DNA Damage and Its Role in Cancer Therapeutics.Semantic proximity Read ↗

DNA damage response, genetic instability and cancer: From mechanistic insights to personalized treatmentSemantic proximity Read ↗

Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment.Semantic proximity Read ↗

DNA repair and the contribution to chemotherapy resistanceSemantic proximity Read ↗

BRCA1 RING Function Is Essential for Tumor Suppression but Dispensable for Therapy ResistanceSemantic proximity Read ↗

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells.Semantic proximity Read ↗

Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome ScreeningSemantic proximity Read ↗

[Roles of BRCA1 and BRCA2 in DNA repair and tumor suppression].Semantic proximity Read ↗

The molecular basis of cancer and the development of targeted therapy.Semantic proximity Read ↗

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer TherapySemantic proximity Read ↗

Exploiting DNA mismatch repair deficiency as a therapeutic strategySemantic proximity Read ↗

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.