A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia.

doi:10.1093/molehr/gan059

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Article

A single base-pair mutation in the 3'-untranslated region of HLA-G mRNA is associated with pre-eclampsia.

Molecular human reproduction - 1 Nov 2008

Yie Shang-mian, Li Liang-hong, Xiao Rong, Librach Clifford L

Abstract excerpt

Human leukocyte antigen-G (HLA-G) is a non-classical class I HLA molecule that is expressed by extravillous cytotrophoblast cells. This protein may play a critical role in the protection of cytotrophoblasts from maternal immune response, allowing these semi-allogeneic cells to invade the uterus unimpeded. We have demonstrated that diminished placental HLA-G expression is associated with pre-eclampsia. In order to...

Topics

3' Untranslated Regions
Adult
Alleles
Base Pairing
Female
Gene Expression Regulation
Genotype
HLA Antigens
HLA-G Antigens
Health
Histocompatibility Antigens Class I
Humans
Mutation
Pre-Eclampsia
Pregnancy
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 18952696
DOI: 10.1093/molehr/gan059

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