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Kinase requirements in human cells: III. Altered kinase requirements in <i>VHL</i> −/− cancer cells detected in a pilot synthetic lethal screen

23 Oct 2008

Abstract excerpt

Clear cell renal carcinomas are the most common form of kidney cancer and frequently are linked to biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. The VHL gene product, pVHL, has multiple functions including directing the polyubiquitylation of the HIF transcription factor. We screened 100 shRNA vectors, directed against 88 kinases, for their ability to inhibit the viability of VHL-/-...

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PMID: 18948595
DOI: 10.1073/pnas.0806574105

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Kinase requirements in human cells: III. Altered kinase requirements in <i>VHL</i> −/− cancer cells detected in a pilot synthetic lethal screenPMID 18948595Read ↗

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