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Article

Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development

23 Oct 2008

Abstract excerpt

Post-translational arginylation mediated by arginyltransferase (Ate1) is essential for cardiovascular development and angiogenesis in mammals and directly affects myocardium structure in the developing heart. We recently showed that arginylation exerts a number of intracellular effects by modifying proteins involved in the functioning of the actin cytoskeleton and in cell motility. Here, we investigated the role...

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PMID: 18948421
DOI: 10.1242/dev.022723

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